Découvrez l'article du mois d'août/septembre des Archives of Cardiovascular Diseases, la revue scientifique en anglais de la SFC :
Association between coffee or tea consumption and cardiovascular outcomes in patients with stable coronary artery disease: Analysis from the CLARIFY registry
Jeremie Abtan, Gregory Ducrocq, Yedid Elbez, Roberto Ferrari, Ian Ford, Kim M. Fox, Jean-Claude Tardif, Michal Tendera, Nicolas Danchin, Alexander Parkhomenko, Christopher M. Reid, P. Gabriel Steg
Abstract
Background: Early cardiac amyloidosis (CA) diagnosis enables patients to access effective treatments forbetter long-term outcomes, yet it remains under-recognised, misdiagnosed and inadequately managed.
Aim: To reduce diagnostic delays, we aimed to describe the epidemiological and clinical characteristicsand changes over an 11-year period.
Methods: This was a retrospective, observational cohort study of all patients referred to the Henri-MondorHospital for suspected CA.
Results: Overall, 3194 patients were identified and 3022 were included and analysed. Our patientscame from varied ethnic backgrounds, and more than half (55.2%) had confirmed CA. Over 11years, referrals increased 4.4-fold, mostly from cardiologists. Notably, wild-type transthyretin amy-loidosis (ATTRwt) became the predominant diagnosis, with referrals increasing 15-fold from 20 in 2010–2012 to 308 in 2019–2020. The number of amyloid light chain (AL) diagnoses increased, whilst variant transthyretin amyloidosis (ATTRv) numbers remained relatively stable. Concerning disease sever-ity, AL patients presented more frequently with severe cardiac involvement whereas an increasing numberof ATTRwt patients presented with National Amyloid Centre stage I (22.0% in 2013–2014 to 45.9% in2019–2020). Lastly, among patients diagnosed with ATTRv in 2019–2020, 83.9% had ATTR Val122Ilecardiac phenotype.
Conclusions: This study shows that increasing cardiologist awareness and referrals have increased CAdiagnoses. With improved awareness and non-invasive diagnostic techniques, more patients with ATTRwtwith milder disease and more ATTRv Val122Ile mutations are being referred and diagnosed. Althoughmore AL cases are being recognised, patients are diagnosed with severe cardiac involvement.
Keywords
• Stable coronary artery disease
• Chronic coronary syndrome
• Coffee